Transcription factors with Perturb-seq knockdown data for ENSG00000248636. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000248636 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000248636, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:119,486,646–119,487,242 | 181.2 kb | Distal (>10kb) Multiome | 69 | |
| chr12:119,667,427–119,668,433 | 218 bp | At TSS Multiome | 901 | |
| chr12:119,804,112–119,804,641 | 136.4 kb | Distal (>10kb) Multiome | 387 | |
| chr12:119,876,730–119,877,837 | 209.3 kb | Distal (>10kb) Multiome | 609 |
Genomic view of the ENSG00000248636 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.