Transcription factors with Perturb-seq knockdown data for ENSG00000245651. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000245651 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000245651, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,888,078–57,888,414 | 8.1 kb | Proximal (<10kb) | 205 | |
| chr12:57,888,522–57,889,064 | 7.4 kb | Proximal (<10kb) | 328 | |
| chr12:57,893,815–57,893,966 | 2.5 kb | Proximal (<10kb) | 259 | |
| chr12:57,896,473–57,897,915 | at TSS | At TSS | 419 | |
| chr12:57,905,368–57,905,733 | 8.9 kb | Proximal (<10kb) | 633 |
Genomic view of the ENSG00000245651 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.