Transcription factors with Perturb-seq knockdown data for ENSG00000244151. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000244151 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000244151, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:151,076,890–151,077,133 | 360 bp | At TSS | 232 | |
| chr7:151,078,687–151,079,073 | 2.2 kb | Proximal (<10kb) | 103 | |
| chr7:151,080,217–151,081,897 | 3.7 kb | Proximal (<10kb) | 909 | |
| chr7:151,083,053–151,083,998 | 6.5 kb | Proximal (<10kb) | 581 | |
| chr7:151,085,505–151,086,758 | 9.0 kb | Proximal (<10kb) | 774 |
Genomic view of the ENSG00000244151 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.