Transcription factors with Perturb-seq knockdown data for ENSG00000243155. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000243155 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000243155, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:180,911,688–180,913,578 | 63.6 kb | Distal (>10kb) Multiome | 364 | |
| chr1:180,922,741–180,923,870 | 53.1 kb | Distal (>10kb) Multiome | 265 | |
| chr1:180,953,870–180,954,644 | 22.1 kb | Distal (>10kb) Multiome | 386 | |
| chr1:181,021,780–181,023,678 | 46.5 kb | Distal (>10kb) Multiome | 965 | |
| chr1:181,088,088–181,090,529 | 112.1 kb | Distal (>10kb) Multiome | 1072 | |
| chr1:181,101,491–181,102,447 | 125.5 kb | Distal (>10kb) Multiome | 425 | |
| chr1:181,104,541–181,106,069 | 128.9 kb | Distal (>10kb) Multiome | 849 | |
| chr1:181,142,277–181,142,792 | 166.1 kb | Distal (>10kb) Multiome | 599 | |
| chr1:181,189,592–181,190,403 | 213.6 kb | Distal (>10kb) Multiome | 413 |
Genomic view of the ENSG00000243155 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.