Transcription factors with Perturb-seq knockdown data for ENSG00000242136. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000242136 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000242136, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:9,095,563–9,096,416 | 7.0 kb | Proximal (<10kb) | 192 | |
| chr2:9,102,820–9,103,037 | 401 bp | At TSS | 171 | |
| chr2:9,103,153–9,103,484 | at TSS | At TSS | 194 | |
| chr2:9,110,578–9,111,244 | 7.1 kb | Proximal (<10kb) | 147 |
Genomic view of the ENSG00000242136 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.