Transcription factors with Perturb-seq knockdown data for ENSG00000241269. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000241269 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000241269, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:5,412,740–5,413,653 | 6.2 kb | Proximal (<10kb) | 341 | |
| chr7:5,417,700–5,419,525 | 301 bp | At TSS | 714 | |
| chr7:5,421,720–5,422,676 | 1.9 kb | Proximal (<10kb) | 485 | |
| chr7:5,423,102–5,425,439 | 3.3 kb | Proximal (<10kb) | 834 | |
| chr7:5,425,593–5,426,138 | 5.8 kb | Proximal (<10kb) | 645 | |
| chr7:5,426,416–5,429,142 | 6.6 kb | Proximal (<10kb) | 1072 |
Genomic view of the ENSG00000241269 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.