Transcription factors with Perturb-seq knockdown data for ENSG00000240963. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000240963 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000240963, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:244,210,968–244,211,448 | 198.3 kb | Distal (>10kb) Multiome | 197 | |
| chr1:244,341,454–244,342,356 | 67.8 kb | Distal (>10kb) Multiome | 361 | |
| chr1:244,353,544–244,354,028 | 55.8 kb | Distal (>10kb) Multiome | 404 | |
| chr1:244,361,460–244,362,746 | 47.6 kb | Distal (>10kb) Multiome | 272 | |
| chr1:244,414,473–244,414,812 | 4.9 kb | Proximal (<10kb) | 38 | |
| chr1:244,450,993–244,452,731 | 42.5 kb | Distal (>10kb) Multiome | 958 | |
| chr1:244,461,143–244,461,971 | 51.9 kb | Distal (>10kb) Multiome | 511 | |
| chr1:244,651,947–244,654,106 | 243.4 kb | Distal (>10kb) Multiome | 921 |
Genomic view of the ENSG00000240963 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.