Transcription factors with Perturb-seq knockdown data for ENSG00000239482. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000239482 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000239482, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:112,085,739–112,087,192 | 216.1 kb | Distal (>10kb) Multiome | 690 | |
| chr3:112,126,419–112,126,878 | 175.8 kb | Distal (>10kb) Multiome | 150 | |
| chr3:112,136,789–112,137,394 | 165.4 kb | Distal (>10kb) Multiome | 233 | |
| chr3:112,293,399–112,294,560 | 8.6 kb | Proximal (<10kb) Multiome | 304 | |
| chr3:112,302,106–112,304,027 | 934 bp | At TSS Multiome | 204 | |
| chr3:112,332,830–112,333,873 | 31.0 kb | Distal (>10kb) Multiome | 281 | |
| chr3:112,390,974–112,391,552 | 88.8 kb | Distal (>10kb) Multiome | 215 | |
| chr3:112,399,211–112,401,142 | 98.0 kb | Distal (>10kb) Multiome | 175 | |
| chr3:112,560,905–112,563,207 | 259.6 kb | Distal (>10kb) Multiome | 967 |
Genomic view of the ENSG00000239482 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.