Transcription factors with Perturb-seq knockdown data for ENSG00000237813. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000237813 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000237813, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:116,499,027–116,500,982 | at TSS | At TSS | 687 | |
| chr7:116,501,554–116,501,720 | 2.1 kb | Proximal (<10kb) | 229 | |
| chr7:116,505,158–116,505,307 | 5.7 kb | Proximal (<10kb) | 16 | |
| chr7:116,505,465–116,505,828 | 6.0 kb | Proximal (<10kb) | 13 | |
| chr7:116,505,950–116,506,124 | 6.5 kb | Proximal (<10kb) | 17 |
Genomic view of the ENSG00000237813 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.