Transcription factors with Perturb-seq knockdown data for ENSG00000236989. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000236989 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000236989, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:15,938,297–15,944,152 | 165.5 kb | Distal (>10kb) Multiome HiCAR | 739 | |
| chr2:15,958,030–15,959,112 | 147.4 kb | Distal (>10kb) Multiome HiCAR | 159 | |
| chr2:15,980,336–15,981,071 | 125.2 kb | Distal (>10kb) Multiome HiCAR | 180 | |
| chr2:16,102,272–16,103,467 | 2.4 kb | Proximal (<10kb) | 259 | |
| chr2:16,104,087–16,104,220 | 1.6 kb | Proximal (<10kb) | 45 | |
| chr2:16,104,408–16,106,306 | 25 bp | At TSS Multiome | 426 |
Genomic view of the ENSG00000236989 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.