Transcription factors with Perturb-seq knockdown data for ENSG00000235978. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235978 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235978, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:4,628,901–4,629,960 | 238.9 kb | Distal (>10kb) Multiome | 233 | |
| chr3:4,867,666–4,869,297 | 93 bp | At TSS Multiome | 812 | |
| chr3:4,975,994–4,976,641 | 107.8 kb | Distal (>10kb) Multiome | 525 | |
| chr3:4,976,933–4,980,833 | 110.5 kb | Distal (>10kb) Multiome | 1341 | |
| chr3:4,985,756–4,987,513 | 117.5 kb | Distal (>10kb) Multiome | 1151 | |
| chr3:5,001,877–5,002,834 | 134.0 kb | Distal (>10kb) Multiome | 452 | |
| chr3:5,016,164–5,017,130 | 148.3 kb | Distal (>10kb) Multiome | 672 | |
| chr3:5,017,970–5,018,615 | 149.8 kb | Distal (>10kb) Multiome | 294 | |
| chr3:5,026,091–5,027,285 | 158.5 kb | Distal (>10kb) Multiome | 782 | |
| chr3:5,122,077–5,123,401 | 254.5 kb | Distal (>10kb) Multiome | 1009 |
Genomic view of the ENSG00000235978 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.