Transcription factors with Perturb-seq knockdown data for ENSG00000235785. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235785 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235785, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:99,262,920–99,263,579 | at TSS | At TSS | 160 | |
| chr14:99,266,620–99,267,125 | 3.7 kb | Proximal (<10kb) | 240 | |
| chr14:99,269,934–99,270,274 | 7.0 kb | Proximal (<10kb) | 176 | |
| chr14:99,270,416–99,271,381 | 7.5 kb | Proximal (<10kb) | 301 | |
| chr14:99,271,901–99,274,036 | 9.0 kb | Proximal (<10kb) | 584 |
Genomic view of the ENSG00000235785 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.