Transcription factors with Perturb-seq knockdown data for ENSG00000235749. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235749 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235749, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:247,356,823–247,358,156 | 282.4 kb | Distal (>10kb) Multiome | 296 | |
| chr1:247,389,944–247,390,543 | 249.3 kb | Distal (>10kb) Multiome | 451 | |
| chr1:247,638,798–247,639,973 | 90 bp | At TSS Multiome | 288 | |
| chr1:247,647,636–247,648,361 | 8.0 kb | Proximal (<10kb) | 192 | |
| chr1:248,825,287–248,827,024 | 1186.5 kb | Distal (>10kb) Multiome HiCAR | 866 |
Genomic view of the ENSG00000235749 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.