Transcription factors with Perturb-seq knockdown data for ENSG00000235192. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235192 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235192, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:165,573,882–165,574,535 | 220.7 kb | Distal (>10kb) Multiome | 319 | |
| chr2:165,697,835–165,698,908 | 96.3 kb | Distal (>10kb) Multiome | 259 | |
| chr2:165,793,126–165,795,058 | 553 bp | At TSS Multiome | 703 | |
| chr2:165,953,255–165,954,562 | 159.1 kb | Distal (>10kb) Multiome | 1143 |
Genomic view of the ENSG00000235192 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.