Transcription factors with Perturb-seq knockdown data for ENSG00000235189. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235189 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235189, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:129,742,000–129,742,555 | 215.2 kb | Distal (>10kb) Multiome | 163 | |
| chrX:129,843,268–129,844,298 | 113.6 kb | Distal (>10kb) Multiome | 523 | |
| chrX:129,905,717–129,906,258 | 51.5 kb | Distal (>10kb) Multiome | 664 | |
| chrX:129,931,017–129,933,134 | 25.2 kb | Distal (>10kb) Multiome | 620 | |
| chrX:129,957,138–129,957,761 | 61 bp | At TSS Multiome | 491 | |
| chrX:129,961,005–129,961,747 | 3.9 kb | Proximal (<10kb) Multiome | 424 | |
| chrX:129,982,008–129,982,922 | 25.0 kb | Distal (>10kb) Multiome | 614 | |
| chrX:130,060,034–130,061,017 | 103.0 kb | Distal (>10kb) Multiome | 583 | |
| chrX:130,120,389–130,121,207 | 163.3 kb | Distal (>10kb) Multiome | 517 | |
| chrX:130,165,452–130,166,368 | 208.4 kb | Distal (>10kb) Multiome | 754 | |
| chrX:130,170,895–130,171,447 | 213.6 kb | Distal (>10kb) Multiome | 203 |
Genomic view of the ENSG00000235189 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.