Transcription factors with Perturb-seq knockdown data for ENSG00000235119. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235119 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235119, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:114,392,159–114,392,493 | 6.0 kb | Proximal (<10kb) | 66 | |
| chr9:114,396,942–114,397,190 | 1.3 kb | Proximal (<10kb) | 248 | |
| chr9:114,397,621–114,398,973 | at TSS | At TSS | 744 | |
| chr9:114,405,604–114,406,064 | 7.1 kb | Proximal (<10kb) | 266 |
Genomic view of the ENSG00000235119 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.