Transcription factors with Perturb-seq knockdown data for ENSG00000235020. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000235020 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000235020, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:17,616,423–17,618,050 | 643.9 kb | Distal (>10kb) Multiome HiCAR | 800 | |
| chr10:18,139,881–18,141,846 | 120.5 kb | Distal (>10kb) Multiome | 429 | |
| chr10:18,251,621–18,252,499 | 8.7 kb | Proximal (<10kb) | 125 | |
| chr10:18,260,457–18,260,957 | 236 bp | At TSS | 11 | |
| chr10:18,261,078–18,261,360 | at TSS | At TSS | 14 |
Genomic view of the ENSG00000235020 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.