Transcription factors with Perturb-seq knockdown data for ENSG00000234418. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000234418 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000234418, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:121,872,464–121,874,098 | 271.4 kb | Distal (>10kb) Multiome | 428 | |
| chr7:121,938,241–121,939,440 | 205.7 kb | Distal (>10kb) Multiome | 264 | |
| chr7:122,143,073–122,145,002 | 185 bp | At TSS Multiome | 722 | |
| chr7:122,299,579–122,300,851 | 155.7 kb | Distal (>10kb) Multiome | 245 | |
| chr7:122,303,627–122,307,580 | 160.3 kb | Distal (>10kb) Multiome | 581 | |
| chr7:122,310,121–122,311,074 | 166.2 kb | Distal (>10kb) Multiome | 257 | |
| chr7:122,316,043–122,317,455 | 172.6 kb | Distal (>10kb) Multiome | 288 | |
| chr7:122,328,635–122,329,533 | 184.8 kb | Distal (>10kb) Multiome | 148 | |
| chr7:122,438,074–122,438,817 | 293.9 kb | Distal (>10kb) Multiome | 200 | |
| chr7:123,533,937–123,535,843 | 1390.4 kb | Distal (>10kb) Multiome HiCAR | 560 |
Genomic view of the ENSG00000234418 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.