Transcription factors with Perturb-seq knockdown data for ENSG00000234261. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000234261 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000234261, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:15,017,392–15,017,686 | 4.3 kb | Proximal (<10kb) | 186 | |
| chr6:15,021,725–15,022,783 | 187 bp | At TSS Multiome | 216 | |
| chr6:15,038,269–15,038,858 | 16.6 kb | Distal (>10kb) Multiome | 88 | |
| chr6:15,243,089–15,243,613 | 221.4 kb | Distal (>10kb) Multiome | 93 | |
| chr6:15,244,671–15,246,133 | 223.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr6:15,247,856–15,249,483 | 226.7 kb | Distal (>10kb) Multiome | 825 | |
| chr6:15,268,231–15,269,003 | 246.7 kb | Distal (>10kb) Multiome | 177 |
Genomic view of the ENSG00000234261 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.