Transcription factors with Perturb-seq knockdown data for ENSG00000234026. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000234026 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000234026, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:95,183,273–95,184,294 | 47.4 kb | Distal (>10kb) Multiome | 664 | |
| chr10:95,229,143–95,229,619 | 1.5 kb | Proximal (<10kb) | 115 | |
| chr10:95,230,238–95,231,843 | 86 bp | At TSS Multiome | 334 | |
| chr10:95,263,812–95,265,078 | 33.5 kb | Distal (>10kb) Multiome | 233 | |
| chr10:95,290,409–95,291,390 | 60.0 kb | Distal (>10kb) Multiome | 671 |
Genomic view of the ENSG00000234026 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.