Transcription factors with Perturb-seq knockdown data for ENSG00000232821. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000232821 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000232821, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:19,106,048–19,108,957 | 3.5 kb | Proximal (<10kb) | 427 | |
| chr7:19,110,900–19,111,309 | 1.2 kb | Proximal (<10kb) | 45 | |
| chr7:19,112,307–19,112,836 | at TSS | At TSS | 130 | |
| chr7:19,116,132–19,119,599 | 3.7 kb | Proximal (<10kb) | 544 | |
| chr7:19,119,862–19,120,132 | 7.4 kb | Proximal (<10kb) | 41 | |
| chr7:19,122,070–19,122,274 | 9.6 kb | Proximal (<10kb) | 85 |
Genomic view of the ENSG00000232821 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.