Transcription factors with Perturb-seq knockdown data for ENSG00000231868. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000231868 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000231868, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:6,438,098–6,438,531 | 8.5 kb | Proximal (<10kb) | 186 | |
| chr1:6,440,165–6,441,114 | 5.9 kb | Proximal (<10kb) | 215 | |
| chr1:6,446,981–6,449,427 | at TSS | At TSS | 665 | |
| chr1:6,455,053–6,455,773 | 8.0 kb | Proximal (<10kb) | 105 |
Genomic view of the ENSG00000231868 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.