Transcription factors with Perturb-seq knockdown data for ENSG00000230790. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000230790 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000230790, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:11,738,589–11,738,787 | 6.5 kb | Proximal (<10kb) | 265 | |
| chr2:11,743,889–11,745,399 | at TSS | At TSS | 874 | |
| chr2:11,745,980–11,747,523 | 679 bp | At TSS | 809 | |
| chr2:11,747,890–11,748,315 | 2.6 kb | Proximal (<10kb) | 149 | |
| chr2:11,753,406–11,754,790 | 8.1 kb | Proximal (<10kb) | 402 |
Genomic view of the ENSG00000230790 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.