Transcription factors with Perturb-seq knockdown data for ENSG00000228862. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000228862 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000228862, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:58,658,535–58,660,031 | 1994.0 kb | Distal (>10kb) Multiome HiCAR | 881 | |
| chr8:60,352,516–60,353,646 | 300.3 kb | Distal (>10kb) Multiome | 94 | |
| chr8:60,516,295–60,517,716 | 136.6 kb | Distal (>10kb) Multiome | 833 | |
| chr8:60,575,730–60,576,435 | 77.5 kb | Distal (>10kb) Multiome | 231 | |
| chr8:60,650,995–60,651,369 | 2.2 kb | Proximal (<10kb) | 77 | |
| chr8:60,651,471–60,652,894 | 1.4 kb | Proximal (<10kb) Multiome | 899 | |
| chr8:60,653,001–60,654,152 | 183 bp | At TSS Multiome | 520 | |
| chr8:60,660,570–60,660,954 | 7.0 kb | Proximal (<10kb) | 311 | |
| chr8:60,676,007–60,676,774 | 22.6 kb | Distal (>10kb) Multiome | 159 | |
| chr8:60,678,041–60,680,775 | 25.1 kb | Distal (>10kb) Multiome | 761 | |
| chr8:60,908,610–60,909,299 | 255.4 kb | Distal (>10kb) Multiome | 412 | |
| chr8:60,921,758–60,923,631 | 269.4 kb | Distal (>10kb) Multiome | 345 | |
| chr8:61,023,190–61,024,662 | 370.2 kb | Distal (>10kb) Multiome HiCAR | 601 | |
| chr8:61,077,575–61,078,562 | 424.5 kb | Distal (>10kb) Multiome HiCAR | 351 |
Genomic view of the ENSG00000228862 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.