Transcription factors with Perturb-seq knockdown data for ENSG00000227627. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227627 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227627, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:151,589,007–151,590,183 | 1394.0 kb | Distal (>10kb) Multiome HiCAR | 147 | |
| chr6:152,681,820–152,683,597 | 300.6 kb | Distal (>10kb) Multiome | 260 | |
| chr6:152,976,675–152,976,927 | 6.4 kb | Proximal (<10kb) | 37 | |
| chr6:152,982,060–152,984,380 | 394 bp | At TSS Multiome | 1096 | |
| chr6:152,993,560–152,993,723 | 9.8 kb | Proximal (<10kb) | 25 | |
| chr6:153,001,940–153,003,776 | 19.1 kb | Distal (>10kb) Multiome | 953 | |
| chr6:153,129,787–153,132,406 | 147.6 kb | Distal (>10kb) Multiome | 562 |
Genomic view of the ENSG00000227627 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.