Transcription factors with Perturb-seq knockdown data for ENSG00000227218. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000227218 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000227218, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:127,926,756–127,928,574 | 9.3 kb | Proximal (<10kb) | 411 | |
| chr9:127,930,321–127,931,068 | 6.8 kb | Proximal (<10kb) | 537 | |
| chr9:127,937,578–127,938,244 | at TSS | At TSS | 674 | |
| chr9:127,942,843–127,943,061 | 5.0 kb | Proximal (<10kb) | 273 | |
| chr9:127,943,778–127,944,132 | 5.9 kb | Proximal (<10kb) | 363 |
Genomic view of the ENSG00000227218 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.