Transcription factors with Perturb-seq knockdown data for ENSG00000226699. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226699 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226699, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:133,087,734–133,088,838 | 262.7 kb | Distal (>10kb) Multiome | 273 | |
| chr10:133,143,227–133,144,444 | 206.7 kb | Distal (>10kb) Multiome | 346 | |
| chr10:133,159,602–133,160,521 | 190.5 kb | Distal (>10kb) Multiome | 198 | |
| chr10:133,229,278–133,231,486 | 120.5 kb | Distal (>10kb) Multiome | 253 | |
| chr10:133,236,052–133,238,686 | 113.0 kb | Distal (>10kb) Multiome | 361 | |
| chr10:133,245,223–133,246,111 | 104.9 kb | Distal (>10kb) Multiome | 265 | |
| chr10:133,247,041–133,247,539 | 103.5 kb | Distal (>10kb) Multiome | 168 | |
| chr10:133,257,420–133,258,249 | 92.9 kb | Distal (>10kb) Multiome | 384 | |
| chr10:133,261,265–133,262,426 | 88.7 kb | Distal (>10kb) Multiome | 421 | |
| chr10:133,276,420–133,277,460 | 73.8 kb | Distal (>10kb) Multiome | 216 | |
| chr10:133,307,807–133,309,623 | 41.6 kb | Distal (>10kb) Multiome | 785 | |
| chr10:133,329,452–133,330,224 | 20.8 kb | Distal (>10kb) Multiome | 471 | |
| chr10:133,347,186–133,347,686 | 3.0 kb | Proximal (<10kb) | 335 | |
| chr10:133,357,077–133,358,582 | 7.2 kb | Proximal (<10kb) Multiome | 649 | |
| chr10:133,373,095–133,373,842 | 22.7 kb | Distal (>10kb) Multiome | 589 | |
| chr10:133,377,993–133,380,099 | 28.5 kb | Distal (>10kb) Multiome | 714 | |
| chr10:133,393,908–133,394,705 | 43.4 kb | Distal (>10kb) Multiome | 959 |
Genomic view of the ENSG00000226699 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.