Transcription factors with Perturb-seq knockdown data for ENSG00000226465. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226465 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226465, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:25,407,111–25,408,013 | 343.6 kb | Distal (>10kb) Multiome | 1021 | |
| chr20:25,550,130–25,551,344 | 200.4 kb | Distal (>10kb) Multiome | 207 | |
| chr20:25,584,579–25,586,173 | 165.7 kb | Distal (>10kb) Multiome | 890 | |
| chr20:25,622,823–25,624,816 | 127.2 kb | Distal (>10kb) Multiome | 1127 | |
| chr20:25,626,372–25,627,565 | 124.4 kb | Distal (>10kb) Multiome | 102 | |
| chr20:25,695,981–25,697,222 | 54.4 kb | Distal (>10kb) Multiome | 1015 | |
| chr20:25,751,008–25,751,421 | at TSS | At TSS | 313 | |
| chr20:25,953,594–25,954,649 | 202.9 kb | Distal (>10kb) Multiome | 41 |
Genomic view of the ENSG00000226465 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.