Transcription factors with Perturb-seq knockdown data for ENSG00000226281. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226281 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226281, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:6,686,589–6,687,652 | 7.4 kb | Proximal (<10kb) | 601 | |
| chr6:6,694,370–6,694,653 | 375 bp | At TSS | 124 | |
| chr6:6,694,873–6,695,432 | at TSS | At TSS | 197 | |
| chr6:6,696,974–6,697,188 | 1.9 kb | Proximal (<10kb) | 183 | |
| chr6:6,697,289–6,697,398 | 2.3 kb | Proximal (<10kb) | 45 | |
| chr6:6,704,420–6,704,917 | 9.4 kb | Proximal (<10kb) | 90 |
Genomic view of the ENSG00000226281 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.