Transcription factors with Perturb-seq knockdown data for ENSG00000226149. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000226149 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000226149, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:129,440,396–129,441,335 | 134.6 kb | Distal (>10kb) Multiome | 227 | |
| chr6:129,565,279–129,565,971 | 9.5 kb | Proximal (<10kb) | 76 | |
| chr6:129,567,320–129,567,669 | 7.8 kb | Proximal (<10kb) | 89 | |
| chr6:129,575,347–129,575,982 | at TSS | At TSS | 218 | |
| chr6:129,709,499–129,710,644 | 134.8 kb | Distal (>10kb) Multiome | 846 | |
| chr6:129,730,874–129,732,365 | 156.3 kb | Distal (>10kb) Multiome | 317 |
Genomic view of the ENSG00000226149 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.