Transcription factors with Perturb-seq knockdown data for ENSG00000225156. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000225156 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000225156, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:44,943,778–44,944,903 | 9.8 kb | Proximal (<10kb) | 119 | |
| chr2:44,945,722–44,946,385 | 8.3 kb | Proximal (<10kb) | 150 | |
| chr2:44,949,379–44,950,322 | 4.3 kb | Proximal (<10kb) | 186 | |
| chr2:44,951,821–44,953,211 | 1.5 kb | Proximal (<10kb) | 430 | |
| chr2:44,955,189–44,956,345 | 525 bp | At TSS | 554 |
Genomic view of the ENSG00000225156 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.