Transcription factors with Perturb-seq knockdown data for ENSG00000223930. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000223930 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000223930, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:176,696,653–176,697,793 | 1688.2 kb | Distal (>10kb) Multiome HiCAR | 174 | |
| chr3:177,196,281–177,198,358 | 1187.9 kb | Distal (>10kb) Multiome HiCAR | 789 | |
| chr3:178,206,465–178,208,041 | 177.8 kb | Distal (>10kb) Multiome | 148 | |
| chr3:178,208,767–178,209,541 | 176.2 kb | Distal (>10kb) Multiome | 100 | |
| chr3:178,211,520–178,212,768 | 173.3 kb | Distal (>10kb) Multiome | 96 | |
| chr3:178,385,447–178,385,655 | at TSS | At TSS | 119 | |
| chr3:178,595,138–178,596,190 | 210.1 kb | Distal (>10kb) Multiome | 165 |
Genomic view of the ENSG00000223930 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.