Transcription factors with Perturb-seq knockdown data for ENSG00000223393. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000223393 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000223393, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:230,641,860–230,643,036 | 226.6 kb | Distal (>10kb) Multiome | 985 | |
| chr1:230,753,346–230,754,251 | 115.0 kb | Distal (>10kb) Multiome | 356 | |
| chr1:230,867,716–230,869,411 | 275 bp | At TSS Multiome | 758 | |
| chr1:230,978,084–230,979,476 | 110.0 kb | Distal (>10kb) Multiome | 931 | |
| chr1:231,039,156–231,041,267 | 171.3 kb | Distal (>10kb) Multiome | 661 | |
| chr1:231,161,989–231,163,833 | 293.5 kb | Distal (>10kb) Multiome | 768 |
Genomic view of the ENSG00000223393 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.