Transcription factors with Perturb-seq knockdown data for ENSG00000222017. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000222017 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000222017, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:197,434,572–197,435,653 | 258.0 kb | Distal (>10kb) Multiome | 937 | |
| chr2:197,452,830–197,454,321 | 239.7 kb | Distal (>10kb) Multiome | 1033 | |
| chr2:197,498,722–197,500,854 | 193.0 kb | Distal (>10kb) Multiome | 1173 | |
| chr2:197,515,482–197,516,752 | 177.1 kb | Distal (>10kb) Multiome | 1138 | |
| chr2:197,586,916–197,587,749 | 105.6 kb | Distal (>10kb) Multiome HiCAR | 118 | |
| chr2:197,704,733–197,706,212 | 12.2 kb | Distal (>10kb) Multiome | 870 | |
| chr2:197,785,007–197,786,878 | 93.2 kb | Distal (>10kb) Multiome | 322 | |
| chr2:197,804,172–197,805,545 | 111.5 kb | Distal (>10kb) Multiome | 556 |
Genomic view of the ENSG00000222017 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.