Transcription factors with Perturb-seq knockdown data for ENSG00000203635. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000203635 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000203635, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:1,387,927–1,388,898 | 237.1 kb | Distal (>10kb) Multiome | 160 | |
| chr2:1,591,763–1,592,421 | 33.3 kb | Distal (>10kb) Multiome | 246 | |
| chr2:1,625,123–1,625,967 | 156 bp | At TSS Multiome | 404 | |
| chr2:1,742,682–1,745,219 | 118.3 kb | Distal (>10kb) Multiome | 477 | |
| chr2:1,817,239–1,818,101 | 192.3 kb | Distal (>10kb) Multiome | 375 | |
| chr2:3,574,766–3,576,282 | 1949.8 kb | Distal (>10kb) Multiome HiCAR | 1145 |
Genomic view of the ENSG00000203635 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.