Transcription factors with Perturb-seq knockdown data for ENSG00000111780. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000111780 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000111780, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:120,429,329–120,429,611 | 8.6 kb | Proximal (<10kb) | 21 | |
| chr12:120,430,441–120,430,724 | 7.5 kb | Proximal (<10kb) | 475 | |
| chr12:120,437,436–120,438,568 | at TSS | At TSS | 725 | |
| chr12:120,439,743–120,439,970 | 1.5 kb | Proximal (<10kb) | 197 | |
| chr12:120,445,927–120,446,970 | 7.7 kb | Proximal (<10kb) | 982 |
Genomic view of the ENSG00000111780 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.