This gene encodes a type-I transmembrane glycoprotein. Studies in rat suggest the encoded protein may play a role in neuronal cell communications. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2014]
Transcription factors with Perturb-seq knockdown data for ENPP5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENPP5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENPP5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:45,900,881–45,901,596 | 269.7 kb | Distal (>10kb) Multiome | 66 | |
| chr6:46,129,365–46,130,543 | 41.0 kb | Distal (>10kb) Multiome | 505 | |
| chr6:46,170,439–46,171,501 | 39 bp | At TSS Multiome | 433 | |
| chr6:46,468,423–46,469,444 | 297.9 kb | Distal (>10kb) Multiome | 97 |
Genomic view of the ENPP5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.