Predicted to enable hormone activity. Predicted to be involved in positive regulation of Notch signaling pathway. Predicted to be located in extracellular region. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ENHO. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENHO upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENHO, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:34,328,711–34,329,961 | 193.6 kb | Distal (>10kb) Multiome | 768 | |
| chr9:34,376,008–34,377,655 | 145.9 kb | Distal (>10kb) Multiome | 779 | |
| chr9:34,379,248–34,381,674 | 142.1 kb | Distal (>10kb) Multiome | 763 | |
| chr9:34,456,881–34,459,235 | 64.3 kb | Distal (>10kb) Multiome | 704 | |
| chr9:34,512,394–34,513,068 | 9.9 kb | Proximal (<10kb) | 276 | |
| chr9:34,513,685–34,513,902 | 9.1 kb | Proximal (<10kb) | 59 | |
| chr9:34,522,211–34,523,972 | 227 bp | At TSS Multiome | 473 | |
| chr9:34,577,374–34,578,752 | 55.0 kb | Distal (>10kb) Multiome | 204 | |
| chr9:34,589,298–34,591,068 | 66.8 kb | Distal (>10kb) Multiome HiCAR | 258 | |
| chr9:34,591,283–34,592,013 | 68.8 kb | Distal (>10kb) Multiome HiCAR | 368 | |
| chr9:34,611,663–34,612,738 | 89.2 kb | Distal (>10kb) Multiome | 680 | |
| chr9:34,612,834–34,613,263 | 90.1 kb | Distal (>10kb) Multiome | 343 | |
| chr9:34,620,108–34,620,704 | 97.5 kb | Distal (>10kb) Multiome | 467 | |
| chr9:34,628,770–34,629,308 | 106.1 kb | Distal (>10kb) Multiome | 216 | |
| chr9:34,637,123–34,638,475 | 114.9 kb | Distal (>10kb) Multiome | 872 | |
| chr9:34,646,247–34,647,338 | 123.7 kb | Distal (>10kb) Multiome | 857 | |
| chr9:34,651,771–34,652,431 | 129.1 kb | Distal (>10kb) Multiome | 669 | |
| chr9:34,664,346–34,666,446 | 142.6 kb | Distal (>10kb) Multiome | 707 | |
| chr9:34,674,895–34,675,574 | 152.3 kb | Distal (>10kb) Multiome | 372 | |
| chr9:34,701,127–34,701,863 | 178.4 kb | Distal (>10kb) Multiome | 390 |
Genomic view of the ENHO locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.