This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]
Transcription factors with Perturb-seq knockdown data for ENGASE. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENGASE upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENGASE, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:78,781,367–78,783,044 | 292.4 kb | Distal (>10kb) Multiome | 847 | |
| chr17:78,839,825–78,841,566 | 233.9 kb | Distal (>10kb) Multiome | 1124 | |
| chr17:78,924,768–78,925,859 | 149.4 kb | Distal (>10kb) Multiome | 498 | |
| chr17:78,971,335–78,971,892 | 103.3 kb | Distal (>10kb) Multiome | 359 | |
| chr17:79,009,356–79,010,250 | 65.0 kb | Distal (>10kb) Multiome | 703 | |
| chr17:79,023,888–79,024,662 | 50.5 kb | Distal (>10kb) Multiome | 348 | |
| chr17:79,074,462–79,075,529 | 3 bp | At TSS Multiome | 657 | |
| chr17:79,182,908–79,183,922 | 108.7 kb | Distal (>10kb) Multiome | 257 |
Genomic view of the ENGASE locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.