ENDOG

endonuclease G

The protein encoded by this gene is a nuclear encoded endonuclease that is localized in the mitochondrion. The encoded protein is widely distributed among animals and cleaves DNA at GC tracts. This protein is capable of generating the RNA primers required by DNA polymerase gamma to initiate replication of mitochondrial DNA. [provided by RefSeq, Jul 2008]

Member of: DE-1

Biological processes 38 terms

DNA catabolic process (GO:0006308)DNA damage response (GO:0006974)DNA endonuclease activity (GO:0004520)DNA endonuclease activity (GO:0004520)DNA endonuclease activity (GO:0004520)DNA nuclease activity (GO:0004536)DNA recombination (GO:0006310)RNA endonuclease activity (GO:0004521)apoptotic DNA fragmentation (GO:0006309)cellular response to calcium ion (GO:0071277)cellular response to glucose stimulus (GO:0071333)cellular response to hypoxia (GO:0071456)cellular response to oxidative stress (GO:0034599)hydrolase activity (GO:0016787)magnesium ion binding (GO:0000287)magnesium ion binding (GO:0000287)metal ion binding (GO:0046872)mitochondrial DNA catabolic process (GO:0032043)mitochondrial inner membrane (GO:0005743)mitochondrion (GO:0005739)mitochondrion (GO:0005739)mitochondrion (GO:0005739)negative regulation of TOR signaling (GO:0032007)negative regulation of TOR signaling (GO:0032007)nucleic acid binding (GO:0003676)nucleus (GO:0005634)perikaryon (GO:0043204)perinuclear region of cytoplasm (GO:0048471)positive regulation of apoptotic DNA fragmentation (GO:1902512)positive regulation of autophagy (GO:0010508)positive regulation of autophagy (GO:0010508)positive regulation of hydrogen peroxide-mediated programmed cell death (GO:1901300)positive regulation of mitochondrial DNA replication (GO:0090297)protein binding (GO:0005515)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)response to estradiol (GO:0032355)response to mechanical stimulus (GO:0009612)

Expression (TPM)

TFs regulating ENDOG 0 TFs

Transcription factors with Perturb-seq knockdown data for ENDOG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENDOG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ENDOG

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENDOG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr9:128,552,006–128,553,125	266.0 kb	Distal (>10kb) Multiome	839
chr9:128,656,436–128,657,126	161.7 kb	Distal (>10kb) Multiome	1009
chr9:128,683,393–128,684,010	134.9 kb	Distal (>10kb) Multiome	296
chr9:128,684,170–128,684,813	133.8 kb	Distal (>10kb) Multiome	574
chr9:128,688,449–128,689,713	129.4 kb	Distal (>10kb) Multiome	805
chr9:128,702,246–128,702,946	115.9 kb	Distal (>10kb) Multiome	720
chr9:128,723,691–128,725,229	94.3 kb	Distal (>10kb) Multiome	821
chr9:128,771,658–128,772,301	46.5 kb	Distal (>10kb) Multiome	940
chr9:128,786,928–128,787,516	31.3 kb	Distal (>10kb) Multiome	1040
chr9:128,818,208–128,819,406	54 bp	At TSS Multiome	839
chr9:128,829,505–128,830,189	11.3 kb	Distal (>10kb) Multiome	782
chr9:128,881,863–128,882,454	63.6 kb	Distal (>10kb) Multiome	777
chr9:128,921,941–128,922,727	103.8 kb	Distal (>10kb) Multiome	378
chr9:128,947,329–128,947,815	129.1 kb	Distal (>10kb) Multiome	865
chr9:129,027,821–129,028,677	209.9 kb	Distal (>10kb) Multiome	639
chr9:129,036,276–129,036,937	218.0 kb	Distal (>10kb) Multiome	736
chr9:129,080,488–129,081,502	262.5 kb	Distal (>10kb) Multiome	755
chr9:129,110,314–129,111,708	292.6 kb	Distal (>10kb) Multiome	881

Genome Browser

Genomic view of the ENDOG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.