Predicted to enable endonuclease activity; metal ion binding activity; and nucleic acid binding activity. Predicted to be involved in innate immune response. Located in extracellular exosome and membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for ENDOD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENDOD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENDOD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:94,973,096–94,974,006 | 116.2 kb | Distal (>10kb) Multiome | 740 | |
| chr11:95,066,821–95,068,191 | 22.4 kb | Distal (>10kb) Multiome | 721 | |
| chr11:95,089,031–95,089,220 | 624 bp | At TSS | 68 | |
| chr11:95,089,389–95,090,696 | 14 bp | At TSS Multiome | 660 | |
| chr11:95,091,154–95,091,462 | 1.3 kb | Proximal (<10kb) | 19 | |
| chr11:95,093,088–95,093,249 | 3.2 kb | Proximal (<10kb) | 170 | |
| chr11:95,107,207–95,108,126 | 17.8 kb | Distal (>10kb) Multiome | 232 | |
| chr11:95,149,652–95,152,295 | 61.7 kb | Distal (>10kb) Multiome | 685 | |
| chr11:95,229,933–95,232,611 | 141.5 kb | Distal (>10kb) Multiome | 696 | |
| chr11:95,788,868–95,791,310 | 700.0 kb | Distal (>10kb) Multiome HiCAR | 1058 |
Genomic view of the ENDOD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.