Transcription factors with Perturb-seq knockdown data for EMX2OS. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMX2OS upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMX2OS, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:117,534,258–117,535,679 | 6.9 kb | Proximal (<10kb) | 184 | |
| chr10:117,536,917–117,538,069 | 4.5 kb | Proximal (<10kb) | 255 | |
| chr10:117,541,368–117,541,582 | 1.0 kb | Proximal (<10kb) | 123 | |
| chr10:117,541,681–117,542,916 | at TSS | At TSS | 423 | |
| chr10:117,543,009–117,544,359 | 420 bp | At TSS | 323 | |
| chr10:117,545,235–117,546,743 | 2.6 kb | Proximal (<10kb) | 183 | |
| chr10:117,547,404–117,547,955 | 4.8 kb | Proximal (<10kb) | 56 | |
| chr10:117,550,690–117,551,001 | 8.1 kb | Proximal (<10kb) | 30 | |
| chr10:117,551,273–117,552,706 | 8.7 kb | Proximal (<10kb) | 291 |
Genomic view of the EMX2OS locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.