The protein encoded by this gene belongs to the PMP-22/EMP/MP20 family of proteins. The protein contains four transmembrane domains and two N-linked glycosylation sites. It is thought to be involved in cell proliferation, cell-cell interactions and function as a tumor suppressor. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for EMP3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMP3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMP3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,169,480–48,171,282 | 151.0 kb | Distal (>10kb) Multiome | 950 | |
| chr19:48,203,709–48,204,551 | 117.5 kb | Distal (>10kb) Multiome | 741 | |
| chr19:48,271,198–48,272,050 | 50.0 kb | Distal (>10kb) Multiome | 562 | |
| chr19:48,290,181–48,291,716 | 30.7 kb | Distal (>10kb) Multiome | 666 | |
| chr19:48,320,062–48,322,328 | 16 bp | At TSS Multiome | 826 | |
| chr19:48,325,262–48,325,620 | 3.8 kb | Proximal (<10kb) | 450 | |
| chr19:48,330,094–48,330,787 | 8.8 kb | Proximal (<10kb) Multiome | 460 | |
| chr19:48,332,701–48,333,506 | 11.4 kb | Distal (>10kb) Multiome | 615 | |
| chr19:48,333,584–48,334,372 | 12.6 kb | Distal (>10kb) Multiome | 554 | |
| chr19:48,363,062–48,364,710 | 42.7 kb | Distal (>10kb) Multiome | 940 | |
| chr19:48,390,663–48,391,935 | 70.1 kb | Distal (>10kb) Multiome | 816 | |
| chr19:48,397,916–48,399,301 | 77.3 kb | Distal (>10kb) Multiome | 619 | |
| chr19:48,399,411–48,400,900 | 79.1 kb | Distal (>10kb) Multiome | 548 | |
| chr19:48,414,121–48,416,085 | 94.0 kb | Distal (>10kb) Multiome | 298 | |
| chr19:48,445,379–48,446,456 | 124.4 kb | Distal (>10kb) Multiome | 845 | |
| chr19:48,468,758–48,470,027 | 147.6 kb | Distal (>10kb) Multiome | 860 | |
| chr19:48,490,661–48,494,449 | 169.8 kb | Distal (>10kb) Multiome | 633 | |
| chr19:48,500,898–48,503,050 | 180.6 kb | Distal (>10kb) Multiome | 656 | |
| chr19:48,510,624–48,511,212 | 189.3 kb | Distal (>10kb) Multiome | 268 | |
| chr19:48,513,480–48,514,294 | 192.4 kb | Distal (>10kb) Multiome | 585 | |
| chr19:48,618,726–48,619,869 | 297.9 kb | Distal (>10kb) Multiome | 1012 | |
| chr19:48,623,839–48,624,688 | 302.7 kb | Distal (>10kb) Multiome | 529 |
Genomic view of the EMP3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.