Predicted to enable microtubule binding activity. Predicted to be located in cytoplasm and microtubule. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EML6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EML6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EML6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:54,455,022–54,458,050 | 267.3 kb | Distal (>10kb) Multiome | 878 | |
| chr2:54,557,613–54,559,353 | 165.3 kb | Distal (>10kb) Multiome | 971 | |
| chr2:54,708,559–54,709,749 | 14.4 kb | Distal (>10kb) Multiome | 252 | |
| chr2:54,722,865–54,724,201 | 37 bp | At TSS Multiome | 895 | |
| chr2:54,724,533–54,725,480 | 1.0 kb | Proximal (<10kb) | 321 |
Genomic view of the EML6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.