Transcription factors with Perturb-seq knockdown data for EML2-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EML2-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EML2-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:45,632,406–45,633,148 | 8.3 kb | Proximal (<10kb) | 358 | |
| chr19:45,638,965–45,639,696 | 1.8 kb | Proximal (<10kb) | 477 | |
| chr19:45,640,813–45,642,557 | at TSS | At TSS | 865 | |
| chr19:45,643,187–45,644,012 | 1.7 kb | Proximal (<10kb) | 542 | |
| chr19:45,645,389–45,646,343 | 3.9 kb | Proximal (<10kb) | 566 |
Genomic view of the EML2-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.