Predicted to enable extracellular matrix constituent conferring elasticity. Involved in several processes, including positive regulation of angiogenesis; positive regulation of defense response to bacterium; and positive regulation of platelet aggregation. Located in extracellular region. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EMILIN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMILIN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMILIN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:2,570,743–2,572,078 | 275.6 kb | Distal (>10kb) Multiome | 906 | |
| chr18:2,654,955–2,656,944 | 191.3 kb | Distal (>10kb) Multiome | 962 | |
| chr18:2,894,188–2,895,797 | 48.0 kb | Distal (>10kb) Multiome HiCAR | 326 | |
| chr18:2,906,043–2,907,458 | 60.0 kb | Distal (>10kb) Multiome | 675 | |
| chr18:3,012,394–3,013,832 | 166.3 kb | Distal (>10kb) Multiome | 816 |
Genomic view of the EMILIN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.