Contributes to membrane insertase activity. Involved in protein insertion into ER membrane by stop-transfer membrane-anchor sequence and tail-anchored membrane protein insertion into ER membrane. Located in endoplasmic reticulum membrane. Part of EMC complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for EMC7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EMC7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EMC7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:33,920,935–33,921,652 | 180.6 kb | Distal (>10kb) Multiome | 112 | |
| chr15:34,038,314–34,039,346 | 63.1 kb | Distal (>10kb) Multiome | 694 | |
| chr15:34,101,337–34,102,390 | 94 bp | At TSS Multiome | 810 | |
| chr15:34,110,185–34,110,311 | 8.3 kb | Proximal (<10kb) | 73 | |
| chr15:34,209,514–34,210,513 | 108.1 kb | Distal (>10kb) Multiome | 775 | |
| chr15:34,224,706–34,225,419 | 123.2 kb | Distal (>10kb) Multiome | 856 | |
| chr15:34,337,012–34,338,557 | 236.1 kb | Distal (>10kb) Multiome | 710 | |
| chr15:34,342,481–34,343,584 | 241.3 kb | Distal (>10kb) Multiome | 845 | |
| chr15:34,366,166–34,368,049 | 264.5 kb | Distal (>10kb) Multiome | 922 |
Genomic view of the EMC7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.