The protein encoded by this gene has a C-terminal domain with tRNA 3′ processing endoribonuclease activity, which catalyzes the removal of the 3' trailer from precursor tRNAs. The protein also interacts with activated Smad family member 2 (Smad2) and its nuclear partner forkhead box H1 (also known as FAST-1), and reduced expression can suppress transforming growth factor-beta induced growth arrest. Mutations in this gene result in an increased risk of prostate cancer. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for ELAC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ELAC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ELAC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:12,730,942–12,731,456 | 286.9 kb | Distal (>10kb) Multiome | 283 | |
| chr17:12,789,314–12,790,678 | 228.5 kb | Distal (>10kb) Multiome | 524 | |
| chr17:12,973,335–12,974,358 | 44.1 kb | Distal (>10kb) Multiome | 136 | |
| chr17:13,017,268–13,018,649 | 43 bp | At TSS Multiome | 828 | |
| chr17:13,024,142–13,024,931 | 6.5 kb | Proximal (<10kb) Multiome | 254 | |
| chr17:14,300,397–14,303,082 | 1282.9 kb | Distal (>10kb) Multiome HiCAR | 904 | |
| chr17:14,308,769–14,310,537 | 1291.4 kb | Distal (>10kb) Multiome HiCAR | 830 |
Genomic view of the ELAC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.