This gene encodes a member of the eukaryotic translation initiation factor 4E binding protein family. The gene products of this family bind eIF4E and inhibit translation initiation. However, insulin and other growth factors can release this inhibition via a phosphorylation-dependent disruption of their binding to eIF4E. Regulation of protein production through these gene products have been implicated in cell proliferation, cell differentiation and viral infection. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for EIF4EBP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF4EBP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF4EBP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:70,116,082–70,116,892 | 287.7 kb | Distal (>10kb) Multiome | 217 | |
| chr10:70,132,124–70,133,061 | 271.4 kb | Distal (>10kb) Multiome | 729 | |
| chr10:70,145,328–70,147,235 | 258.5 kb | Distal (>10kb) Multiome | 1006 | |
| chr10:70,169,902–70,171,034 | 233.5 kb | Distal (>10kb) Multiome | 777 | |
| chr10:70,232,204–70,234,260 | 170.5 kb | Distal (>10kb) Multiome | 949 | |
| chr10:70,381,835–70,383,091 | 21.5 kb | Distal (>10kb) Multiome | 693 | |
| chr10:70,403,687–70,404,709 | 64 bp | At TSS Multiome | 788 | |
| chr10:70,405,410–70,405,754 | 1.3 kb | Proximal (<10kb) | 369 | |
| chr10:70,437,649–70,438,147 | 33.8 kb | Distal (>10kb) Multiome | 93 | |
| chr10:70,439,787–70,443,007 | 38.5 kb | Distal (>10kb) Multiome | 501 | |
| chr10:70,455,031–70,455,839 | 51.3 kb | Distal (>10kb) Multiome | 196 | |
| chr10:70,458,264–70,459,984 | 54.5 kb | Distal (>10kb) Multiome | 310 | |
| chr10:70,478,010–70,479,323 | 74.6 kb | Distal (>10kb) Multiome | 492 | |
| chr10:70,672,118–70,672,962 | 268.4 kb | Distal (>10kb) Multiome | 465 |
Genomic view of the EIF4EBP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.