This gene encodes a translation initiation factor involved in the recruitment and delivery of aminoacyl-tRNAs to the P-site of the eukaryotic ribosome in a GTP-independent manner. This gene was previously referred to as ligatin, but is now known to localize to the cytoplasm and localize and function with translation factors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]
Transcription factors with Perturb-seq knockdown data for EIF2D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EIF2D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EIF2D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:206,490,111–206,490,584 | 122.2 kb | Distal (>10kb) Multiome | 320 | |
| chr1:206,506,880–206,508,298 | 104.9 kb | Distal (>10kb) Multiome | 469 | |
| chr1:206,544,602–206,545,089 | 67.5 kb | Distal (>10kb) Multiome | 336 | |
| chr1:206,556,960–206,557,656 | 55.2 kb | Distal (>10kb) Multiome | 540 | |
| chr1:206,612,122–206,612,956 | 74 bp | At TSS Multiome | 1157 | |
| chr1:206,634,849–206,636,243 | 23.1 kb | Distal (>10kb) Multiome | 899 | |
| chr1:206,658,246–206,658,769 | 46.2 kb | Distal (>10kb) Multiome | 346 | |
| chr1:206,663,840–206,664,482 | 51.8 kb | Distal (>10kb) Multiome | 337 | |
| chr1:206,684,490–206,685,847 | 72.4 kb | Distal (>10kb) Multiome | 492 | |
| chr1:206,687,758–206,688,437 | 75.6 kb | Distal (>10kb) Multiome | 218 | |
| chr1:206,909,139–206,910,281 | 297.1 kb | Distal (>10kb) Multiome | 445 |
Genomic view of the EIF2D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.